BTTES (CCT-1237)

Description

BTTES is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation.

Specifications

Documents

Selected References

1. Banerjee, C., et al. (2022). Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET. J Vis Exp., 186. [PubMed]
2. Schamber, M. R., et al. (2022). Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2. Elife, 11:e78982. [PubMed]
3. Schamber, M. R., et al. (2022). Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning. Nat Commun., 13 (1), 2194. [PubMed]
4. BSoriano del Amo, D., et al. (2010). Biocompatible copper(I) catalysts for in vivo imaging of glycans J. Am. Chem. Soc.,. 132(47): 16893–9. [PubMed]