Bioconjugation

Conjugate with confidence

Leverage bioconjugation to expand your molecular toolbox and create the perfect match for your research needs. SoluLINK® bioconjugation technology is engineered for high-performance conjugation of all classes of biomolecules, including antibodies, proteins, peptides, oligonucleotides, carbohydrates, drugs, and surfaces. The result is reliable, quantifiable labeling delivering ready-to-use conjugates at high yield.

Want to learn more?

Join us for our June 2, 2021 Webinar: An Introduction to Bioconjugation

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Bioconjugation Resource Guide: Methodology to Linking Technology

This guide provides an overview of bioconjugation, applications and uses, as well as tools for successful bioconjugation.

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Fully Integrated Bioconjugation kits using SoluLINK technology

Fully Integrated Kit

From conjugation to purification, our fully integrated kits ensure the generation of high-quality conjugates, free of unincorporated label.

Conjugate biomolecules with high yield using SoluLINK technology

High Yield

Leverage efficient labeling, without a need for heavy metal catalysts, to prepare biomolecule conjugates at high yield with uncompromised purity.

Reliably conjugate biomolecules using SoluLINK technology

Reliable

With mild reaction conditions and high affinity conjugate chemistry, you’ll generate consistent results with an unparalleled level of reproducibility across experiments.

Directly quantify conjugation using SoluLINK technology

Quantifiable

Monitor and record conjugation progress in real-time with a UV-traceable chromophore, enabling direct quantification to confirm experimental success.

Conjugate a variety of biomolecules using versatile SoluLINK technology

Flexible

With versatile technology to conjugate and capture all biomolecules, our product portfolio and expertise are available to ensure successful scaleup of your conjugation needs from micrograms to grams to kilos.

 
 

Quantitative and Reproducible Bioconjugation with SoluLINK Technology

Explore the bioconjugation workflow and considerations for selecting a conjugation strategy.

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How it works

SoluLINK technology uses an innovative linker-based strategy to chemically join two molecules to form a single hybrid with a novel function. The chemistry is based on the reaction of an aromatic hydrazine (HyNic) with an aromatic aldehyde (4FB), which forms a stable bis-aryl hydrazone bond. This UV-traceable chromophore helps ensure experimental success with direct quantification to:

  • Determine of the number of linkers incorporated on each biomolecule prior to conjugation
  • Monitor and record the conjugation reaction in real time
  • Measure of the number of linkages formed in the conjugate and the precise number of biomolecules or ligands attached

Explore bioconjugation reagents

Conjugation Kits

From conjugation to purification, our fully integrated kits ensure the generation of conjugates at high yield, with direct quantification to ensure experimental success.
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Magnetic Beads & Agarose

NanoLINK® and MagnaLINK® streptavidin magnetic beads, as well as and streptavidin agarose, provide up to 15-times greater biotin binding capacity than other commercially available products.
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Biotin and Digoxigenin Labeling Reagents

ChromaLINK® Biotin and Digoxigenin products enable accurate, controlled incorporation of labels on biomolecules, without the need the need to carry out cumbersome and time-consuming HABA/avidin and fluoro-reporter assays.
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Looking to scale your conjugation with maximum performance?

Our extensive portfolio and bioconjugation experts are available to ensure successful scale-up of conjugation for your application.

Conjugation Linkers

To meet your needs for scale-up conjugation, amine-reactive NHS ester and thiol-reactive maleimide versions of HyNic, 4FB, Biotin, and Digoxigenin linkers are available as stand-alone options.
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Bioconjugation Ancillary Products

Stand-alone linkers and reagents for scale-up manufacturing.
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Custom & OEM Services

Our dedicated team of scientists & chemists has extensive expertise in conjugation and we provide a number of custom and OEM services.
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Questions?

Check out our FAQs or connect with an expert to learn more.

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