Bioconjugation
Conjugate with confidence
Leverage bioconjugation to expand your molecular toolbox and create the perfect match for your research needs. SoluLINK® bioconjugation technology is engineered for high-performance conjugation of all classes of biomolecules, including antibodies, proteins, peptides, oligonucleotides, carbohydrates, drugs, and surfaces. The result is reliable, quantifiable labeling delivering ready-to-use conjugates at high yield.
Webinar: An Introduction to Bioconjugation
Bioconjugation Resource Guide: Methodology to Linking Technology
This guide provides an overview of bioconjugation, applications and uses, as well as tools for successful bioconjugation.
Fully Integrated Kits
From conjugation to purification, our fully integrated kits ensure the generation of high-quality conjugates, free of unincorporated label.
Reliable
With mild reaction conditions and high affinity conjugate chemistry, you’ll generate consistent results with an unparalleled level of reproducibility across experiments.
Flexible
With versatile technology to conjugate and capture all biomolecules, our product portfolio and expertise are available to ensure successful scaleup of your conjugation needs from micrograms to grams to kilos.
High Yield
Leverage efficient labeling, without a need for heavy metal catalysts, to prepare biomolecule conjugates at high yield with uncompromised purity.
Quantifiable
Monitor and record conjugation progress in real-time with a UV-traceable chromophore, enabling direct quantification to confirm experimental success.
Quantitative and Reproducible Bioconjugation with SoluLINK Technology
Explore the bioconjugation workflow and considerations for selecting a conjugation strategy.
How it works
SoluLINK technology uses an innovative linker-based strategy to chemically join two molecules to form a single hybrid with a novel function. The chemistry is based on the reaction of an aromatic hydrazine (HyNic) with an aromatic aldehyde (4FB), which forms a stable bis-aryl hydrazone bond. This UV-traceable chromophore helps ensure experimental success with direct quantification to:
- Determine of the number of linkers incorporated on each biomolecule prior to conjugation
- Monitor and record the conjugation reaction in real time
- Measure of the number of linkages formed in the conjugate and the precise number of biomolecules or ligands attached
Explore bioconjugation reagents
From conjugation to purification, our fully integrated kits ensure the generation of conjugates at high yield, with direct quantification to confirm experimental success.
NanoLINK® and MagnaLINK® streptavidin magnetic beads, as well as and streptavidin agarose, provide up to 15-times greater biotin binding capacity than other commercially available products.
From conjugation to purification, our fully integrated kits ensure the generation of conjugates at high yield, with direct quantification to confirm experimental success.
Looking to scale your conjugation with maximum performance?
Our extensive portfolio and bioconjugation experts are available to confirm successful scale-up of conjugation for your application.
To meet your needs for scale-up conjugation, amine-reactive NHS ester and thiol-reactive maleimide versions of HyNic, 4FB, Biotin, and Digoxigenin linkers are available as stand-alone options.
Stand-alone linkers and reagents for scale-up manufacturing.
Our dedicated team of bioconjugation experts are available to suggest conjugation and purification strategies for maximum performance in your application.
Questions?
Check out our FAQs or connect with an expert to learn more.
References:
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