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Conjugate with confidence

Leverage bioconjugation to expand your molecular toolbox and create the perfect match for your research needs. SoluLINK® bioconjugation technology is engineered for high-performance conjugation of all classes of biomolecules, including antibodies, proteins, peptides, oligonucleotides, carbohydrates, drugs, and surfaces. The result is reliable, quantifiable labeling delivering ready-to-use conjugates at high yield.

Webinar: An Introduction to Bioconjugation

Bioconjugation Resource Guide: Methodology to Linking Technology

This guide provides an overview of bioconjugation, applications and uses, as well as tools for successful bioconjugation.

BioCon Guide Pages

Fully Integrated Kits

From conjugation to purification, our fully integrated kits ensure the generation of high-quality conjugates, free of unincorporated label.



With mild reaction conditions and high affinity conjugate chemistry, you’ll generate consistent results with an unparalleled level of reproducibility across experiments.



With versatile technology to conjugate and capture all biomolecules, our product portfolio and expertise are available to ensure successful scaleup of your conjugation needs from micrograms to grams to kilos.

High Yield

High Yield

Leverage efficient labeling, without a need for heavy metal catalysts, to prepare biomolecule conjugates at high yield with uncompromised purity.



Monitor and record conjugation progress in real-time with a UV-traceable chromophore, enabling direct quantification to confirm experimental success.

Quantitative and Reproducible Bioconjugation with SoluLINK Technology

Explore the bioconjugation workflow and considerations for selecting a conjugation strategy.

Biocon Pages

How it works

SoluLINK technology uses an innovative linker-based strategy to chemically join two molecules to form a single hybrid with a novel function. The chemistry is based on the reaction of an aromatic hydrazine (HyNic) with an aromatic aldehyde (4FB), which forms a stable bis-aryl hydrazone bond. This UV-traceable chromophore helps ensure experimental success with direct quantification to:

  • Determine of the number of linkers incorporated on each biomolecule prior to conjugation
  • Monitor and record the conjugation reaction in real time
  • Measure of the number of linkages formed in the conjugate and the precise number of biomolecules or ligands attached

Explore bioconjugation reagents

From conjugation to purification, our fully integrated kits ensure the generation of conjugates at high yield, with direct quantification to confirm experimental success.

NanoLINK® and MagnaLINK® streptavidin magnetic beads, as well as and streptavidin agarose, provide up to 15-times greater biotin binding capacity than other commercially available products.

From conjugation to purification, our fully integrated kits ensure the generation of conjugates at high yield, with direct quantification to confirm experimental success.

Looking to scale your conjugation with maximum performance?

Our extensive portfolio and bioconjugation experts are available to confirm successful scale-up of conjugation for your application.

To meet your needs for scale-up conjugation, amine-reactive NHS ester and thiol-reactive maleimide versions of HyNic, 4FB, Biotin, and Digoxigenin linkers are available as stand-alone options.

Stand-alone linkers and reagents for scale-up manufacturing.

Our dedicated team of bioconjugation experts are available to suggest conjugation and purification strategies for maximum performance in your application.


Check out our FAQs or connect with an expert to learn more.


  1. O’Huallachain M. et al. 2020. Ultra-high throughput single-cell analysis of proteins and RNAs by split-pool synthesisCommunications Biology
  2. Wang HB. et al. 2020. The establishment and clinical evaluation of a novel, rapid, no-wash one-step immunoassay for the detection of dengue virus non-structural protein 1Journal of Virological Methods
  3. Akazawa Y. et al. 2019. Higher human lymphocyte antigen class I expression in early-stage cancer cells leads to high sensitivity for cytotoxic T lymphocytesCancer Science
  4. Kaur M. et al. 2019. Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in MiceThe Journal of Immunology
  5. Setliff I. et al. 2019. High-Throughput Mapping of B Cell Receptor Sequences to Antigen SpecificityCell
  6. Wu D. et al. 2019. Profiling surface proteins on individual exosomes using a proximity barcoding assayNature Communications
  7. Yeo KT. et al. 2019. HIV, Cytomegalovirus, and Malaria Infections during Preg¬nancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan NeonatesThe Journal of Immunology
  8. Baldo B. et al. 2018. Quantification of Total and Mutant Huntingtin Protein Levels in Biospecimens Using a Novel alphaLISA AssayeNeuro
  9. Janco M. et al. 2018. Interactions of tropomyosin Tpm1.1 on a single actin filament: A method for ex¬traction and processing of high resolution TIRF microscopy dataPLOS ONE
  10. Klaesson A. et al. 2018. Improved efficiency of in situ protein analysis by proximity ligation using UnFold probesScientific Reports
  11. Lee J. et al. 2018. Accelerated FRET-PAINT microscopyMolecular Brain
  12. Thinn AMM. et al. 2018. The membrane-distal regions of integrin α cytoplasmic domains contribute differently to integrin inside-out activationScientific Reports
  13. Ambrosetti E. et al. 2017. Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder NanoarraysACS Omega
  14. Sehlin D. et al. 2017. Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-βScientific Reports
  15. Han BG. et al. 2016. Long shelf-life streptavidin support-films suitable for electron microscopy of biological macromoleculesJournal of Structural Biology
  16. Sehlin D. et al. 2016. Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s diseaseNature Communications
  17. Gu Urban G. et al. 2015. Elevated Serum GAD65 and GAD65-GADA Immune Complexes in Stiff Person SyndromeScientific Reports
  18. Volpetti F. et al. 2015. A Microfluidic Platform for High-Throughput Multiplexed Protein QuantitationPLOS ONE
  19. Hammond M. et al. 2014. Sensitive detection of aggregated prion protein via proximity ligationPrion
  20. Torres AJ. et al. 2013. Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowellsLab on a Chip
  21. Malviya G. et al. 2009. Radiolabeled Humanized Anti-CD3 Monoclonal Antibody Visilizumab for Imaging Human T-LymphocytesJournal of Nuclear Medicine
  22. Liu G. et al. 2007. A novel pretargeting method for measuring antibody internalization in tumor cellsCancer Biotherapy & Radiopharmaceuticals
  23. Dirksen A. & Dawson PE. 2008. Rapid Oxime and Hydrazone Ligations with Aromatic Aldehydes for Biomolecular LabelingBioconjugate Chemistry
  24. Dirksen A. et al. 2006. Nucleophilic Catalysis of Hydrazone Formation and Transimination: Implications for Dynamic Covalent ChemistryJournal of the American Chemical Society