BTTP is a newest generation, accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering copper loading in the catalyst formulation.


Unit Size100 mg, 500 mg, 1000 mg
Molecular weight430.56
Chemical compositionC20H34N10O
SolubilityDMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Maiyun, Y., et al. (2014). Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coliNature Communications5: 4981. [PubMed]
  2. Wang, W., et al. (2011). Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition. Chem Asian J.6(10), 2796-802. [PubMed]

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