TBTA was introduced shortly after the copper-catalyzed azide-alkyne cycloaddition reaction was discovered to mitigate thermodynamic instability of Cu(I) in aerobic media. TBTA is a water-insoluble ligand and must be first dissolved in DMSO or DMF.


Unit Size100 mg, 500 mg, 1 g
Molecular weight530.62
Chemical compositionC30H30N10
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Selected References

  1. David, L. L., et al. (2021). Chemical Proteomics Approach for Profiling the NAD Interactome. J Am Chem Soc.143 (18), 6787-6791. [PubMed]
  2. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107. [JoVE Journal]
  3. Pratt Matthew R., et al. (2020). Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins. Frontiers in Chemistry, 8, 318. [Frontiers in Chemistry]
  4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501. [PubMed]

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