BTTES is a newest generation, water-soluble accelerating ligand for CuAAC that provides much greater rate enhancement compared to previous generation ligands (e.g. THPTA or TBTA). More importantly, it minimizes perturbations to the physiological state of the cells or organisms probed and allows for effective bioconjugation with suppressed cell cytotoxicity by further lowering Cu loading in the catalyst formulation.


Unit Size100 mg, 500 mg, 1000 mg
Molecular weight494.62
Chemical compositionC20H34N10O3
SolubilityWater, DMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceOff-white to grey solid
Storage Conditions4°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Banerjee, C., et al. (2022). Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET. J Vis Exp., 186. [PubMed]
  2. Schamber, M. R., et al. (2022). Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2. Elife, 11:e78982. [PubMed]
  3. Schamber, M. R., et al. (2022). Mechanism of sensitivity modulation in the calcium-sensing receptor via electrostatic tuning. Nat Commun.13 (1), 2194. [PubMed]
  4. BSoriano del Amo, D., et al. (2010). Biocompatible copper(I) catalysts for in vivo imaging of glycans J. Am. Chem. Soc.,132(47): 16893–9. [PubMed]

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