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t-boc-N-amido-dPEG®₄-OH (QBD-10250)



t-boc-N-amido-dPEG®4-OH, product number QBD-10250, is a short, monodispersed PEGylation reagent with an alcohol on one end of the single molecular weight, discrete-length PEG (dPEG®) chain and a boc-protected amine on the other end. This product is useful for building novel constructs with dPEG® linkers. This product also permits supramolecular construction and unique side-chain modifications of amino acid residues in peptides.

The terminal alcohol of t-boc-N-amido-dPEG®4-OH can be transformed easily into a different functional group such as an aldehyde or acid. Moreover, the hydroxy group reacts with halide-functionalized compounds to form new products. For example, by reacting propargyl bromide with the terminal hydroxy group in the presence of a base, a dPEG® product with an aliphatic alkyne is formed. Thus, t-boc-N-amido-dPEG®4-OH is a building block for new constructs that incorporate a discrete-length PEGylation product.
The boc-protected amine easily deprotects with trifluoroacetic acid or another acid. The exposed amine may be reacted further or left unmodified.


Unit Size100 mg, 1000 mg
Molecular Weight293.36; single compound
Chemical formulaC₁₃H₂₇NO₆
Purity> 97%
SpacersdPEG® Spacer is 13 atoms and 14.3 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or moderate solubility in water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Effects of linker variation on the in vitro and in vivo characteristics of an In-labeled RGD peptide, Ingrid Dijkgraaf, Shuang Liu, John A.W. Kruijtzer, Annemieke C. Soede, Wim J.G. Oyen, Rob M.J. Liskamp, Frans H.M. Corstens, Otto C. Boerman. Nuclear Medicine and Biology. 2007, 1 (34), pp 29-35, January 2007. DOI: 10.1016/j.nucmedbio.2006.10.006.

Applicable patents and legal notices are available at legal notices.

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