TCO-PEG4-NHS Ester (CCT-A137)


TCO-PEG4-NHS Ester is a pegylated lebeling reagent with enhanced solubility in aqueous buffers used for TCO labeling of antibodies, proteins and other primary amine-containing macromolecules. A long, hydrophilic PEG4 spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary tetrazine-containing molecules.


Unit Size4x2mg, 10mg, 25mg, 100mg
Molecular weight514.57
Chemical compositionC24H38N2O10
SolubilityDMSO, DMF, THF, Acetonitrile, Dichloromethane
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsDry ice

Selected References

  1. Ingham, E. S., et al. (2020). Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation. Nat Commun, 11, 2102. [Nature Communications]
  2. Sun, N., et al. (2020). Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring. Nat Commun.11, 4489. [PubMed]
  3. Allo, B., et al. (2018). Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjugate Chem. 29(6), 2028-38. [PubMed]

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