TCO Reagents
Trans-cyclooctene (TCO) Reagents are highly reactive components used in Click Chemistry for bioorthogonal labeling and cross-linking applications. TCOs rapidly and specifically react with tetrazines in inverse-electron-demand Diels–Alder (IEDDA) reactions, enabling efficient conjugation under physiological conditions. When incorporated into DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) linkers, TCOs facilitate membrane-targeted labeling and controlled drug delivery systems.
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