TCO-PEG3-Maleimide (CCT-1002)

Description

TCO-PEG3-Maleimide enables simple and efficient incorporation of TCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. The hydrophilic polyethylene glycol (PEG) spacer arm improves solubility in aqueous buffers.

Specifications

Unit Size4 x 2 mg, 10 mg, 25 mg, 100 mg
Molecular weight523.62
Molecular formulaC26H41N3O8
CAS1609659-01-9
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsOvernight, dry ice

Selected References

  1. Allo, B., et al. (2018). Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjugate Chem. 29(6), 2028-38. [PubMed]

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