Methyltetrazine-PEG4-NHS Ester

Methyltetrazine-PEG4-NHS Ester reacts specifically and efficiently with a primary amine (e.g., side chain of lysine residues or aminosilane-coated surfaces) at pH 7-9 to form a covalent bond. The PEG spacer arm provides a long and flexible connection that minimizes steric hindrance involved with ligation to complementary TCO-containing molecules. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.

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SKU: CCT-1069
CAS Number
1802907-92-1
Molecular Weight
533.53
Appearance
Red crystalline
Chemical Formula
C24H31N5O9
Purity
>95% (HPLC)
Unit Size
4×2 mg, 10mg, 25 mg, 100 mg, 500
Solubility
DMSO, DMF, DCM, THF, Chloroform
Storage Instructions
-20°C. Desiccate
Shipping Conditions
Ambient temperature
Shipping Instructions
Ambient temperature
Selected References
  1. Marquard, A.N., et al. (2020). Expanding the Scope of Antibody Rebridging with New Pyridazinedione-TCO Constructs. Bioconjug Chem., 31(6), 1616-23. [PubMed]