DBCO-PEG4-Maleimide

DBCO-PEG4-Maleimide enables simple and efficient incorporation of DBCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. The hydrophilic polyethylene glycol (PEG) spacer arm improves solubility in aqueous buffers.

Price range: $149.00 through $1,983.00

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SKU: CCT-A108P
CAS Number
1480516-75-3
Molecular Weight
674.74
Appearance
Yellow to slightly orange oil
Chemical Formula
C36H42N4O9
Purity
>95% (HPLC)
Unit Size
10mg, 25mg, 100mg, 500mg
Solubility
DMSO, DMF, DCM, THF, Chloroform
Storage Instructions
-20°C. Desiccate
Shipping Conditions
Frozen
Shipping Instructions
Frozen
Selected References
  1. Esser-Kahn, A. P., et al. (2020). Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci., 10, 1021. [ACS Publications]
  2. Kiseleva, R., et al. (2020). MBivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo. FASEB Jornal, 34, 9, 11577-93. [FASEB]