DBCO-PEG4-Maleimide (CCT-A108P)


DBCO-PEG4-Maleimide enables simple and efficient incorporation of DBCO moiety onto antibodies, cysteine-containing peptides and other thiol-containing molecules. The maleimide group specifically and efficiently reacts with reduced thiols (sulfhydryl groups, –SH) at pH 6.5 to 7.5 to form stable thioether bonds. The hydrophilic polyethylene glycol (PEG) spacer arm improves solubility in aqueous buffers.


Unit Size10mg, 25mg, 100mg, 500mg
Molecular weight674.74
Chemical compositionC36H42N4O9
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceYellow to slightly orange oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Esser-Kahn, A. P., et al. (2020). Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci., 10, 1021. [ACS Publications]
  2. Kiseleva, R., et al. (2020). MBivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo. FASEB Jornal, 34, 9, 11577-93. [FASEB]

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