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Propargyl amine (QBD-10510)

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Description

Propargyl amine, product number QBD-10510, is an amine-functionalized, three-carbon, terminal aliphatic alkyne. A non-dPEG® product, propargyl amine (formally, prop-2-yn-1-amine) is an alkynyl partner for Quanta BioDesign’s azide-functionalized dPEG®-based click chemistry reagents. Click chemistry using propargyl amine and azides requires catalysis. Copper(I) catalysis leads to the 1,3-dipolar cycloaddition product. Ruthenium catalysis forms the 1,5-dipolar cycloaddition product. The terminal amine can be reacted with any of Quanta BioDesign’s dPEG® NHS or TFP esters or carboxylic acid products to form any desired product.

Specifications

Unit Size1000 mg
Molecular Weight55.08; single compound
Chemical formulaC₃H₅N
CAS2450-71-7
Purity> 98%
SpacersSpacer is 4 atoms and 3.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); pp. 722-716 (Greg has several general protocols on pp. 725-726).

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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