Alkyne-PEG4-NHS Ester (CCT-TA103)


Alkyne-PEG4-NHS Ester is a labeling reagent that can be used to modify primary amine groups (e.g., a side chain of lysine residues or aminosilane-coated surfaces) with a terminal alkyne group via a stable, covalent amide bond. The terminal alkyne group can be reacted with azides via CuAAC enabling efficient and specific conjugation of derivatized molecules in biological samples.


Unit Size25 mg, 100 mg, 1000 mg
Molecular weight401.41
Chemical compositionC18H27NO9
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Selected References

  1. Graham, A. J., et al. (2022). Extracellular Electron Transfer Enables Cellular Control of Cu(I)-Catalyzed Alkyne-Azide Cycloaddition. ACS Cent Sci.8 (2), 246-257. [PubMed]
  2. Hu, Y., Glazier, R., et al. (2021). DNA-based microparticle tension sensors (µTS) for measuring cell mechanics in non-planar geometries and for high-throughput quantification. Angew Chem Int Ed Engl., Online ahead of print. [PubMed]

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