CBZ-N-amido-dPEG®4-acid, product number QBD-10268, is a benzyl carbamate (Cbz) N-protected amino-dPEG®-acid that provides a short, single molecular weight discrete PEG (dPEG®) spacer. Designed for use in peptide synthesis, it can also be used in many other reactions. In peptide synthesis, the removal of the Cbz protecting group is orthogonal to many other protecting groups.
The Cbz protecting group (also called the Z protecting group) is one of the most popular protecting groups for amines. It is stable in mildly basic and acidic conditions. A variety of methods cleave the Cbz group. The most popular cleavage technique is hydrogenolysis, using palladium black or palladium on carbon.
Unit Size | 100 mg, 1000 mg |
---|---|
Molecular Weight | 399.44; single compound |
Chemical formula | C₁₉H₂₉NO₈ |
CAS | 756526-00-8 |
Purity | > 98% |
Spacers | dPEG® Spacer is 17 atoms and 19.2 Å |
Shipping | Ambient |
Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, DMAC or DMSO. |
Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
Applicable patents and legal notices are available at legal notices.
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