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Azido-dPEG®₇-amine (QBD-10523)



Azido-dPEG®7-amine, product number QBD-10523, is a carbonyl-reactive, biocompatible crosslinking reagent that can participate in multiple types of reactions. The product consists of an azide group and an amine group on opposite ends of a single molecular weight, discrete polyethylene glycol (dPEG®) chain. Alkynes react with the azido group in metal-catalyzed or strain-promoted click chemistry to yield triazole derivatives. Moreover, the azide group functions as a masked amine that reduces to a primary amine via a suitable reducing agent. Furthermore, Azido-dPEG®7-amine can participate in a Staudinger ligation with appropriate phosphine derivatives to create a water-soluble product.

The amphiphilic dPEG® product adds hydrodynamic volume and imparts water solubility to any compound to which it is conjugated. Also, because the terminal azide group functions in multiple different types of reactions, Azido-dPEG®7-amine can act as either a heterobifunctional, click chemistry crosslinker or a monoprotected homobifunctional crosslinking reagent.


Unit Size100 mg, 1000 mg
Molecular Weight394.46; single compound
Chemical formulaC₁₆H₃₄N₄O₇
Purity> 98%
SpacersdPEG® Spacer is 25 atoms and 28.8 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Tuning the Properties of Layer-by-Layer Assembled Poly(acrylic acid) Click Films and Capsules. Cameron R. Kinnane, Georgina K. Such, and Frank Caruso. Macromolecules, 2011, 44 (5), pp 1194–1202 February 4, 2010. DOI: 10.1021/ma102593k.

Detection of SK2 Channels on Hippocampal Neurons. Jamie L. Maciaszek University of Connecticut (2012) DigitalCommons@Uconn Master’s Theses Paper 237 April 20, 2012.

The development of peptide–boron difluoride formazanate conjugates as fluorescence imaging agents. Neha Sharmaa, Stephanie M. Barbona, Tyler Lalondea, Ryan R. Maara, Mark Milneb, Joe B. Gilroy and Leonard G. Luyt. RSC Adv., 2020, 10, 18970-18977. May 19th, 2020. DOI: 10.1039/D0RA02104K

Applicable patents and legal notices are available at legal notices.

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