6-Azidohexanoic Acid (CCT-1250)


6-Azidohexanoic acid is a six carbon saturated fatty acid with an ω-terminal azide group. This building block that can be reacted with primary amine groups in the presence activators (e.g. EDC, or DCC) forming a stable amide bond. The terminal azide group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is commonly used as a linker that is first acylated to one compound to create a derivative that can then be joined to another compound using click chemistry.


Unit Size1 g, 5 g, 25 g
Molecular weight157.17
Chemical compositionC6H11N3O2
SolubilityDMSO, DMF, DCM, THF, Chloroform
Purity>95% (HPLC)
AppearanceColorless to slightly yellow oil
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Selected References

  1. Esser-Kahn, A. P., et al. (2020). Pathogen-like Nanoassemblies of Covalently Linked TLR Agonists Enhance CD8 and NK Cell-Mediated Antitumor Immunity. ACS Cent. Sci., 10, 1021. [ACS Publications]
  2. Manna, S., et al. (2018). Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent. Sci.4(8), 982-95. [PubMed]

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