MAL-dPEG®6-NHS ester, product number QBD-10064, is a crosslinking reagent that joins a sulfhydryl to a free amine across a hydrophilic bridge. The sulfhydryl groups react with a maleimide group via a Michael addition reaction. The amines form amide bonds with the crosslinker by nucleophilic substitution of the N-hydroxysuccinimidyl (NHS) ester of a carboxylic acid group. The maleimide and NHS functional groups on the crosslinking compound sit at either end of a short, discrete-length polyethylene glycol chain (dPEG®).
Unit Size | 100 mg, 1000 mg |
---|---|
Molecular Weight | 601.60; single compound |
Chemical formula | C₂₆H₃₉N₃O₁₃ |
CAS |
1137109-21-7
|
Purity | > 98% |
Spacers |
dPEG® Spacer is 28 atoms and 31.7 Å |
Shipping |
Ambient |
Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, Acetonitrile, DMAC or DMSO. |
Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Applicable patents and legal notices are available at legal notices.
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