MAL-dPEG®₂-acid

MAL-dPEG®2-acid, product number QBD-10265, is a crosslinker that joins sulfhydryl groups to free amines through a single molecular weight polyethylene glycol (PEG) chain of discrete length (dPEG®). The maleimidopropyl moiety reacts with sulfhydryl groups via a Michael addition reaction. The propionic acid terminus of the molecule reacts directly with free amines using EDC or another carbodiimide to form amide bonds. Alternatively, activation of the propionic acid group with N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), or some other acylating agent permits amide bond formation under mild, controlled conditions.

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SKU: QBD-10265
CAS Number
756525-98-1
Molecular Weight
328.32; single compound
Chemical Formula
C₁₄H₂₀N₂O₇
Purity
> 98%
Unit Size
100 mg, 1000 mg
Solubility
Methylene chloride, Acetonitrile, DMAC or DMSO.
Spacers
dPEG® Spacer is 16 atoms and 17.5 Å
Storage Instructions
-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.
Shipping Instructions
Ambient