MAL-dPEG®6-acid, product number QBD-10065, is a crosslinker that joins sulfhydryl groups to free amines through a single molecular weight, discrete length polyethylene glycol (dPEG®) chain. The maleimidopropyl moiety reacts with sulfhydryl groups via a Michael addition reaction. The propionic acid terminus of the molecule reacts directly with free amines using EDC or another carbodiimide to form amide bonds. Alternatively, activation of the propionic acid group with N-hydroxysuccinimide (NHS), 2,3,5,6-tetrafluorophenol (TFP), or some other acylating agent permits amide bond formation under mild, controlled conditions.
Unit Size | 100 mg, 1000 mg |
---|---|
Molecular Weight | 504.53; single compound |
Chemical formula | C₂₂H₃₆N₂O₁₁ |
CAS |
1334177-79-5
|
Purity | > 98% |
Spacers |
dPEG® Spacer is 28 atoms and 31.9 Å |
Shipping |
Ambient |
Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, Acetonitrile, DMAC or DMSO. |
Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Applicable patents and legal notices are available at legal notices.
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