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m-dPEG®₈-Thiol (QBD-10793)



m-dPEG®8-thiol, product number QBD-10793, is a short (26 atoms) monodisperse PEGylation reagent designed to modify gold and silver surfaces or biomolecules that contain free, surface-accessible thiols. One end of the spacer terminates with a methyl group, while the other end terminates with a sulfhydryl. The sulfhydryl group forms dative bonds with gold or silver, disulfides with free thiols, and thioether bonds with maleimide and bromoacetate groups.

This product is useful for the passivation of gold or silver surfaces. The hydrophilic, non-immunogenic dPEG® spacer eliminates non-specific interactions with the metal surfaces.

If reacted with free thiols on biomolecules, m-dPEG®8-thiol forms disulfide bonds. Moreover, the resulting conjugates display improved water solubility and increased hydrodynamic volume. Furthermore, conjugation of this product with biomolecules potentially reduces or eliminates non-specific interactions and immunogenicity.


Unit Size100mg, 1000mg
Molecular Weight400.53; single compound
Chemical formulaC₁₇H₃₆O₈S
Purity> 98%
SpacersdPEG® Spacer is 26 atoms and 30.0 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and Frederick R. Haselton, Langmuir, 2012, 28 (4), pp 2187–2193 December 9, 2011.

(INVITED)Quantitative detection of SARS-CoV-2 virions in aqueous mediums by IoT optical fiber sensors. Nunzio Cennamo, Girolamo D’Agostino, Laura Pasquardini, Francesco Arcadio, Chiara Perri, Nicola Coppola, Italo Francesco Angelillo, Lucia Altucci, Francesco Di Marzo, Eva Maria Parisio, Giulio Camarlinghi, Luigi Zeni. Science Direct. Volume 5.

Applicable patents and legal notices are available at legal notices.

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