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m-dPEG®₈-amine (QBD-10278)



m-dPEG®8-amine, product number QBD-10278, is a methyl-terminated PEG amine compound. The PEG is a water-soluble, single molecular weight PEG product with a discrete chain length (dPEG®). Carboxylic acids and their active esters react with the amino terminus to form amide bonds. Furthermore, the amino terminus reacts with aldehydes and ketones, forming reducible Schiff bonds. Uses for m-dPEG®8-amine include modification of acid-functionalized surfaces and free carboxylic acid groups on biomolecules.

In published scientific literature, the following applications have utilized m-dPEG®8-amine:
Development of probes for continuous real-time modification of renal function;
Surface functionalization of magnetic iron nanoparticles;
PEGylation of PAMAM dendrimers to modify cytotoxicity and transfection efficiency; and,
Surface coating of carbon nanotubes used for thermally controllable extraction and separation of peptides.


Unit Size100 mg, 1000 mg
Molecular Weight383.48; single compound
Chemical formulaC₁₇H₃₇NO₈
Purity> 98%
SpacersdPEG® Spacer is 26 atoms and 29.7 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Surface functionalization of magnetic iron oxide nanoparticles for MRI applications –effect of anchoring group and ligand exchange protocol. Eric D. Smolensky, Hee-Yun E. Park, Thelma S. Berquo and Valerie C. Pierre. Contrast Media Mol. Imaging. 2010, 6 (4), pp 189-199. August 2010. DOI:10.1002/cmmi.417.

New optical probes for the continuous monitoring of renal function. Richard B. Dorshow, Bethel Asmelash, Lori K. Chinen, Martin P. Debreczeny, Richard M. Fitch, John N. Freskos, Karen P. Galen, Kimberly R. Gaston, Timothy A. Marzan, Amruta R. Poreddy, Raghavan Rajagopalan, Jeng-Jong Shieh, William L. Neumann. Proc. SPIE 6867, Molecular Probes for Biomedical Applications II. 2008. 68670C. February 13,2008. DOI:10.1117/12.763697.

Effects of PEGylation and Acetylation of PAMAM Dendrimers on DNA Binding, Cytotoxicity and in Vitro Transfection Efficiency. Kristina Fant, Elin K. Esbjörner, Alan Jenkins, Martin C. Grossel, Per Lincoln, and Bengt Nordén. Mol. Pharmaceutics. 2010, 7 (5) pp 1734–1746. August 9, 2010. DOI: 10.1021/mp1001312.

Soft Nanotubes Derivatized with Short PEG Chains for Thermally Controllable Extraction and Seperation of Peptides. Naohiro Kameta, Wuxiao Ding, and Jiuchao Dong. ACS Omega. 2017, 2, pp 6143-6150. September 26, 2017. DOI: 10.1021/acsomega.7b00838.

Benzene tricarboxamide derivatives with lipid and ethylene glycol chains self-assemble into distinct nanostructures driven by molecular packing, Nada Aljuaid a, Mark Tully b, Jani Seitsonen c, Janne Ruokolainen c and Ian W. Hamley, ChemComm, 2021, 57, 8360, 07/27/2021, DOI: 10.1039/d1cc03437e

Applicable patents and legal notices are available at legal notices.

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