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m-dPEG®₁₅-amine (QBD-10298)

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Description

m-dPEG®15-amine, product number QBD-10298, is a non-immunogenic, water-soluble chemical modification reagent. The product contains a monodisperse, single molecular weight, discrete-length polyethylene glycol (dPEG®) chain terminated on one end with a methyl group and the other end with an amine. The amino group reacts with carboxylic acids (and their active esters) to form amide bonds. Reactions with aldehydes or ketones form a labile imine known as a Schiff base, which can be reduced to form a secondary amine. Direct conjugation of carboxylic acids and m-dPEG®15-amine require a carbodiimide such as EDC. Uses for this product include passivating surfaces, coating biomolecules, and building dendrimers and other supramolecular constructs.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight691.85; single compound
Chemical formulaC₃₁H₆₅NO₁₅
CAS32130-27-1
Purity> 98%
SpacersdPEG® Spacer is 47 atoms and 53.4 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Dendrimers for Imaging and Molecular Sieving. Stuart Alexander McNelles. Doctoral Dissertations, McMaster University: Hamilton, Ontario, 2019.

Benzene tricarboxamide derivatives with lipid and ethylene glycol chains self-assemble into distinct nanostructures driven by molecular packing, Nada Aljuaid a, Mark Tully b, Jani Seitsonen c, Janne Ruokolainen c and Ian W. Hamley, ChemComm, 2021, 57, 8360, 07/27/2021, DOI: 10.1039/d1cc03437e

Applicable patents and legal notices are available at legal notices.

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