Fmoc-N-amido-dPEG®₃-acid (QBD-10033)

Description

Fmoc-N-amido-dPEG®3-acid, product number QBD-10033, is one of a broad line of products designed for use in peptide synthesis. The short (13 atoms), discrete PEG (dPEG®) spacer is functionalized with a propionic acid group on one end and Fmoc-protected amine on the other. The product can be added to the N-terminus of a growing peptide chain or to a primary-amine-functionalized side chain of an amino acid such as lysine. The dPEG®3 spacer imparts water solubility to the peptide to which it is conjugated.

QBD-10033 permits our customers to insert a dPEG® spacer into a peptide chain using familiar Fmoc chemistry using solid phase or solution phase chemistry. The dPEG® compound can be inserted at either end of the peptide chain or in the middle of two amino acid sequences to provide a flexible linker between distinct functional peptides. Additionally, the dPEG® spacer can be used to provide spacing in a synthetic construct where steric hindrance is a problem. The amphiphilic nature of dPEG® products means that the construct gains hydrodynamic volume and water solubility while remaining soluble in organic solvent. The Fmoc protecting group removes easily with a solution of piperidine in N,N-dimethylformamide (DMF).

Specifications

Documents

References

1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
   
   
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6. Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement. Sasaki K, Harada M, Yoshikawa T, Tagawa H, Harada Y, Yonemitsu Y, Ryujin T, Kishimura A, Mori T, Katayama Y. Preprint from ChemRxiv, 14 Jul 2020
   DOI: 10.26434/chemrxiv.12654602.v1 PPR: PPR187646
   
   
7. Peptide Amphiphilic-Based Supramolecular Structures with Anti-HIV-1 Activity. Gómara Elena, María José, Pons Pons, Ramon; Herrera, Carolina, Ziprin, Paul, Haro Villar, Isabel Haro. Bioconjugate Chemistry. 2021. Volume 32, Issue 9. 07/13/2021. DOI: 10.1021/acs.bioconjchem.1c00292