Water-soluble, substrate for sortase mediated labeling of proteins. Sortase catalyzes a transpeptidase reaction between a specific internal sequence of a protein and an amine group present on the N-terminus of triglycine recently has become an area of great interest. This method of labeling proteins has been denoted as “Sortagging”.
Proteins conjugated to DBCO-Gly-Gly-Gly can be further modified with azide-containing molecules creating site-specific protein conjugates. Examples of creating protein conjugates using sortagging include site-specifically PEGylating proteins,1 site-specific protein-lipid conjugates,2 and constructing peptides and glycosylphosphatidylinositol chimeras.3 Sortase has also been used in peptide synthesis to cyclize peptides to create macrocyclic peptides, glycopeptides4 and protein−protein conjugates.
Unit Size | 10 mg, 25 mg, 100 mg |
---|---|
Molecular weight | 598.63 |
Chemical composition | C274H30N6O8S |
CAS | N/A |
Solubility | Water, DMSO, DMF |
Purity | >90% (HPLC) |
Appearance | Yellow solid |
Storage Conditions | -20°C. Desiccate |
Shipping Conditions | Frozen |
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