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Cy3 Methyltetrazine (CCT-1018)

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Description

Methyltetrazine-activated Cy3 probe that reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is a bioorthogonal reaction that possesses exceptional kinetics (k > 800 M-1 -1) and selectivity. Such excellent reaction rate constants are unparalleled by any other bioorthogonal reaction pair described to date. described to date.

Cy®3 is a bright, water-soluble, and pH insensitive orange-fluorescent dye that can be excited using the 532 nm or 555 nm laser line and visualized with TRITC (tetramethylrhodamine) filter sets. Cy3 conjugates give less background than TAMRA and most other commonly used fluorescent dyes.

Cy®Dye is a trademark of GE Healthcare

Specifications

Unit Size1 mg, 5 mg, 25 mg
Abs/Em Maxima553/569 nm
Extinction Coefficient
150,000
Flow Cytometry Laser Line532 or 555 nm
Microscopy Laser Line532 or 555 nm
Spectrally Similar DyesAlexa Fluor® 555, Atto™ 555, CF™ 555 Dye, DyLight™549
Molecular weight908.07
CAS1676067-48-3
SolubilityWater, DMSO, DMF, MeOH
Purity>95% (HPLC)
AppearanceRed solid
Storage Conditions-20°C. Desiccate
Shipping ConditionsAmbient temperature

Abs/Em Spectra

Cy Cy

Selected References

  1. Marquard, A.N., et al. (2020). Expanding the Scope of Antibody Rebridging with New Pyridazinedione-TCO Constructs. Bioconjug Chem.31(6), 1616-23. [PubMed]

Applicable patents and legal notices are available at legal notices.

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