Bis-dPEG®₅-acid (QBD-10230)

Description

Bis-dPEG®5-acid, product number QBD-10230, is a short, monodisperse, homobifunctional polyethylene glycol (PEG) compound designed for crosslinking amines. Two propionic acid groups terminate either end of a discrete PEG (dPEG®) chain. These two end groups can be coupled directly to amines using a carbodiimide such as EDC. Alternatively, the carboxylate ends can be functionalized as active esters. Reactive groups such as NHS, TFP, PFP, and HOBt are suitable for this purpose. Reaction with various amines follows the activation step.

The hydrophilic dPEG® spacer imparts water solubility and flexibility to molecules to which it is conjugated. Moreover, conjugates containing dPEG® moieties have increased hydrodynamic volume. Also, the non-immunogenic crosslinker reduces or eliminates the antigenicity of the resulting conjugates.

Peptides, proteins, amine-containing biomolecules, and small molecules with primary or secondary amine groups can all be crosslinked with Bis-dPEG®5-acid. It may also be useful for peptide stapling or as a building block for macromolecular constructs.

Specifications

Documents

References

1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.