Biotin-dPEG®23-MAL, product number QBD-10785, is a thiol-reactive biotinylation product built on a long (77 atoms), single molecular weight, discrete PEG (dPEG®) spacer. The maleimide group is a useful, highly popular reactive group for conjugating to free thiol groups in biomolecules. Maleimide groups can be conjugated to free thiol groups in the pH range from 6.5 – 7.5, forming a stable thioether linkage. The dPEG® spacer in this product is highly hydrophilic and increases the conjugate’s water solubility.
| Unit Size | 25 mg, 100 mg, 1000 mg |
|---|---|
| Molecular Weight | 1450.72; single compound |
| Chemical formula | C₆₅H₁₁₉N₅O₂₈S |
| CAS | 1334172-60-9 |
| Purity | > 95% |
| Spacers | dPEG® Spacer is 77 atoms and 94.1 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | Methylene chloride, DMAC or DMSO. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
Integrin-Generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions. Carol Jurchenko, Yuan Chang, Yoshie Narui, Yun Zhang, Khalid S. Salaita. Biophysical Journal. 2014, 106 (7) pp 1436-1446. 4/1/2017. DOI: 10.1016/j.bpj.2014.01.049.
Applicable patents and legal notices are available at legal notices.
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