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Aminooxy-dPEG®₁₁-azide.HCl (QBD-10538)

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Description

Aminooxy-dPEG®11-azide.HCl, product number QBD-10538, is a click chemistry crosslinker functionalized with an oxyamine moiety on one end of a medium-length (38 atoms), single molecular weight, discrete PEG (dPEG®) linker, and an azide group on the other end. The azide end of the linker reacts with aliphatic or cyclic alkynes through copper-catalyzed (CuAAC), ruthenium-catalyzed (RuAAC), or strain-promoted, copper-free (SPAAC) click chemistry to form a triazole ring. The molecule’s aminooxy end (sold as an HCl salt) reacts with aldehydes and ketones to form biocompatible, stable oxime bonds that are important in many bioconjugation and supramolecular construction processes.

Specifications

Unit Size50 mg, 1000 mg
Molecular Weight623.134
Chemical formulaC₂₄H₅₁CIN₄O₁₂
CASN/A
Purity> 95%
SpacersdPEG® Spacer is 38 atoms and 40.8Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Water, DCM, or methanol
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his chapter 18 on discrete PEG compounds.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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