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Vector Laboratories is closed for the President’s Day on Monday, February 19th. We will be back in the office on Tuesday, February 20th.
We will respond to emails upon our return. Have a wonderful day.
Amino-dPEG®6-acid, product number QBD-10067, is a PEGylated amino acid consisting of a primary amine and a propionic acid on opposite ends of a polyethylene glycol (PEG) spacer. The flexible PEG spacer is discrete (Ð = 1), having a single chain length and molecular weight. Moreover, it is highly hydrophilic, increasing the hydrodynamic volume and imparting water solubility to conjugates that incorporate it. Furthermore, Amino-dPEG®6-acid is helpful in wide-ranging applications, including peptide synthesis, surface modification, dendrimer construction, and small molecule modification.
| Unit Size | 100 mg, 1000 mg |
|---|---|
| Molecular Weight | 353.41; single compound |
| Chemical formula | C₁₅H₃₁NO₈ |
| CAS | 905954-28-1 |
| Purity | > 98% |
| Spacers | dPEG® Spacer is 22 atoms and 25.1 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | DMAC or DMSO or water. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Synthesis and Preliminary Biological Evaluation of High-Drug-Load Paclitaxel-Antibody Conjugates for Tumor-Targeted Chemotherapy. Sherly Quiles, Kevin P. Raisch, Leisa L. Sanford, James A. Bonner, and Ahmad Safavy, J Med. Chem. 2010, 53 (2), pp 586-594. Dec. 3, 2009. DOI: 10.1021/jm900899g.
TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Jaehee Kim, Juhyun Oh, Hannah M Peterson, Jonathan C T Carlson, Mikael J Pittet, Ralph Weissleder. Advanced Biology. 2022. Volume 6, Issue 8. June 8, 2022. https://doi.org/10.1002/adbi.202200030
Applicable patents and legal notices are available at legal notices.
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