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Vector Laboratories is closed for the President’s Day on Monday, February 19th. We will be back in the office on Tuesday, February 20th.
We will respond to emails upon our return. Have a wonderful day.
Amino-dPEG®4-acid, product number QBD-10244, is an amino PEG acid. A primary amine and propionic acid terminate the ends of the polyethylene glycol (PEG) spacer. The single molecular weight PEG spacer is discrete (Ð = 1) and highly hydrophilic. Consequently, it increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it.
Both ends of the molecule are available for conjugation. Conjugation of only one end of the dPEG® spacer may modify the overall charge of the conjugate. Many different types of coupling reactions are effective for this purpose. However, care should be taken not to use single-step EDC coupling, as this will polymerize the dPEG® product.
In the scientific literature, this product has been used to modify diverse compounds, including protein microarrays, biological molecules such as antibodies, RGD dimers, and labeled nucleotides. In each case, amino-dPEG®4-acid was shown to improve sensitivity by increasing the signal-to-noise ratio, reducing non-specific binding, or both.
| Unit Size | 100 mg, 1000 mg |
|---|---|
| Molecular Weight | 265.30; single compound |
| Chemical formula | C₁₁H₂₃NO₆ |
| CAS | 663921-15-1 |
| Purity | > 98% |
| Spacers | dPEG® Spacer is 16 atoms and 18.0 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | DMAC or DMSO or water. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Carboxyl-Terminated Dendrimer-Coated Bioactive Interface for Protein Microarray: High-Sensitivity Detection of Antigen in Complex Biological Samples. Parayil Kumaran Ajikumar, Jin Kiat Ng, Yew Chung Tang, Jim Yang Lee, Gregory Stephanopoulos, and Heng-Phon Too. Langmuir. 2007, 23 (10) pp 5670–5677. March 28, 2007. DOI: 10.1021/la063717u.
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Microwave-Mediated Synthesis of Labeled Nucleotides with Utility in the Synthesis of DNA Probes. Mark Lefever, Jerome W. Kosmeder, II, Michael Farrell, and Christopher Bieniarz. Bioconjugate Chemistry. 2010, 21 (10) pp 1773–1778. September 2, 2010. DOI: 10.1021/bc100013b.
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Influence of Different Spacers on the Biological Profile of a DOTA-Somatostatin Analogue. Patricia Antunes, Mihaela Ginj, Martin A. Walter, Jianhua Chen, Jean-Claude Reubi, and Helmut R. Maecke. Bioconjugate Chemistry. 2007, 18 (1) pp 84–92. December 15, 2006. DOI: 10.1021/bc0601673.
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes. Kohei Sano, Takahito Nakajima, Kiminori Miyazaki, Yuya Ohuchi, Takashi Ikegami, Peter L. Choyke and Hisataka Kobayashi. Bioconjugate Chemistry. 2013, 24 (5) pp 811–816. April 22, 2013. DOI: 10.1021/bc400050k.
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Improving Tumor-Targeting Capability and Pharmacokinetics of 99mTc-Labeled Cyclic RGD Dimers with PEG4 Linkers. Lijun Wang, Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Bing Jia, Huiyun Zhao, Zhaofei Liu, Fan Wang, Xiaoyuan Chen and Shuang Liu. Molecular Pharmaceutics. 2009, 6 (1) pp 231–245. December 9, 2008. DOI: 10.1021/mp800150r.
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Improving Tumor Uptake and Pharmacokinetics of 64Cu-Labeled Cyclic RGD Peptide Dimers with Gly3 and PEG4 Linkers. Jiyun Shi, Young-Seung Kim, Shizhen Zhai, Zhaofei Liu, Xiaoyuan Chen and Shuang Liu. Bioconjugate Chemistry. 2009, 20 (4) pp 750–759. March 25, 2009. DOI: 10.1021/bc800455p.
HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules. Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani. Molecular Therapy Nucleic Acids. 2021. Volume 27, Page 165-174. November 29, 2021. https://doi.org/10.1016/j.omtn.2021.11.021
Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma. Christine Mehner, Alexandra Hockla, Mathew Coban, Benjamin Madden, Rosendo Estrada, Derek C Radisky, Evette S Radisky. Journal Of Biological Chemistry. 2022. Volume 298, Issue 8. June 16, 2022. https://doi.org/10.1016/j.jbc.2022.102146
TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Jaehee Kim, Juhyun Oh, Hannah M Peterson, Jonathan C T Carlson, Mikael J Pittet, Ralph Weissleder. Advanced Biology. 2022. Volume 6, Issue 8. June 8, 2022. https://doi.org/10.1002/adbi.202200030
Multiplexed single-cell analysis of FNA allows accurate diagnosis of salivary gland tumors. Juhyun Oh, Tae Yeon Yoo, Talia M Saal, Lisa Tsay , William C Faquin, Jonathan C T Carlson, Daniel G Deschler, Sara I Pai MD PhD, Ralph Weissleder MD PhD. ACS Journals. 2022. Volume 130, Issue 8, p. 581-594. June 6, 2022. https://doi.org/10.1002/cncy.22594.
In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy. Jina Ko, Kilean Lucas, Rainer Kohler, Elias A Halabi, Marin Wikovitsch, Johathan C T Carlson, Ralph Weissleder. Wiley Online Library. 2022. Volume 9, Issue 24. June 24, 2022. https://doi.org/10.1002/advs.202200064
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