Amino-dPEG®24-amido-dPEG®24-acid, product number QBD-10907, is a PEGylated amino acid consisting of a primary amine group on one end and a propionic acid group sit on opposite ends of a long (152 atoms, 178.9 Å), single molecular weight polyethylene glycol (PEG) spacer with a discrete chain length (dPEG®). The dPEG® spacer consists of two dPEG®24 chains joined by an amide bond, giving the spacer the effective length of a dPEG48 linker. The highly hydrophilic, discrete PEG spacer (Ð = 1) increases the hydrodynamic volume and imparts water solubility to conjugates that incorporate it. Moreover, Amino-dPEG®24-amido-dPEG®24-acid may benefit numerous applications, including peptide synthesis, peptide modification, surface modification, oligonucleotide sequencing, drug delivery, and small molecule modification.
| Unit Size | 100 mg, 1000 mg |
|---|---|
| Molecular Weight | 2274.72; single compound |
| Chemical formula | C₁₀₂H₂₀₄N₂O₅₁ |
| CAS | N/A |
| Purity | > 97% |
| Spacers | dPEG® Spacer is 152 atoms and 178.9 Å |
| Shipping | Ambient |
| Typical solubility properties (for additional information contact Customer Support) | DMAC or DMSO or water. |
| Storage and handling | -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure. |
Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.
Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
Applicable patents and legal notices are available at legal notices.
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