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AMCA Acid (FP-1235)

Description

AMCA Acid (7-amino-4-methylcoumarin-3-acetic acid) is one of the most popular blue fluorescent tagging molecules. Often used as contrasting probes for double- and triple-labeling inimmunofluorescence microscopy, arrays and in situ hybridization. The desirable properties of AMCA dyes include a relatively large Stoke’s shift and resistance to photobleaching.

AMCA Acid is a reagent of choice for the preparation of custom activated esters that often are not commercially available. Examples of such activated esters include sulfo-NHS, TFP (2,3,5,6-Tetrafluorophenol), STP (4-Sulfo-2,3,5,6-Tetrafluorophenol, Sodium Salt). Another common application for non-activated carboxylic acid is peptide modification during solid phase synthesis, which usually requires in-situ activation with peptide coupling regents, for example HATU. AMCA Acid is also often used for control experiments, and for calibration.

Specifications

Unit Size25 mg, 100 mg, 1000 mg
ReactivityPrimary amines (needs activation)
Abs/Em Maxima345/450 nm
Extinction coefficient19,000 cm-1M-1
SolubilityDMSO, DMF
Spectrally similar dyesAlexa Fluor® 350, AMCA, DyLight® 350
Molecular weight233.27
Storage Conditions-20°C.
Shipping ConditionsAmbient temperature

Abs/Em Spectra

Amca Abs Em Amca abs em

Applicable patents and legal notices are available at legal notices.

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