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Acid-dPEG®₂₅-NHS ester (QBD-10140)

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Description

Acid-dPEG®25-NHS ester, product number QBD-10140, is an amine-reactive crosslinker that is designed to facilitate intermolecular crosslinking with free amines at each end of the crosslinker through a single molecular weight, discrete polyethylene glycol (dPEG®) backbone. Because one end of the chain terminates in a propionic acid group while the other end terminates as the N-hydroxysuccinimidyl (NHS) ester of propionic acid, this product can effectively overcome the problems typically afflicting homobifunctional crosslinkers. Moreover, the carboxylic acid end can remain unmodified, allowing the carboxylic acid to be used as a charge modifier in supramolecular and bioconjugate construction. Furthermore, the non-immunogenic amphiphilic dPEG® backbone imparts water solubility to conjugate molecules, which can improve the performance of conjugates.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1316.47; single compound
Chemical formula C₅₈H₁₀₉NO₃₁
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 79 atoms and 92.5 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene Chloride, Acetonitrile, DMF, DMSO or DMAC.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Small Molecule–Protein Hybrid for Voltage Imaging via Quenching of Bioluminescence. Brittany R. Benlian, Pavel E. Z. Klier, Kayli N. Martinez, Marie K. Schwinn, Thomas A. Kirkland, and Evan W. Miller. ACS Sensors. 2021. 03/16/2021. DOI: 10.1021/acssensors.1c00058

Applicable patents and legal notices are available at legal notices.

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