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4-formyl-benzamido-dPEG®₂₄-TFP ester (QBD-10082)

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Description

4-formyl-benzamido-dPEG®24-TFP ester, product number QBD-10082, is useful for introducing an aryl aldehyde into a peptide, protein, or other biomolecules. The 2,3,5,6-tetrafluorophenyl (TFP) ester end reacts with free amines, while the flexible, non-immunogenic, discrete PEG (dPEG®) spacer adds water solubility to the conjugate. Reacting the aldehyde moiety with a hydrazide or aminooxy reactive group forms hydrazone or oxime bonds, respectively.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 1426.53; single compound
Chemical formula C₆₅H₁₀₇F₄NO₂₈
CAS N/A
Purity > 97%
Spacers dPEG® Spacer is 83 atoms and 93.0 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) DMF, DMAC, or DMSO.
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0); See pp. 276-335 for general description and use of heterobifunctional crosslinkers, and the specific sample protocol for SPDP and LC-SPDP on pp. 286-288. See Greg’s extensive index on pp. 1192-1193 for references to a number and range of applications and their respective protocols.

  2. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  3. Strategies for Neoglycan Conjugation to Human Acid r-Glucosidase. Qun Zhou, James E. Stefano, John Harrahy, Patrick Finn, Luis Avila, Josephine Kyazike, Ronnie Wei, Scott M. Van Patten, Russell Gotschall, Xiaoyang Zheng, Yunxiang Zhu, Tim Edmunds, and Clark Q. Pan. Bioconjugate Chem. 2011, 22 pp 741–751. March 18, 2011. doi.org/10.1021/bc1005416

  4. Single-Step Conjugation of Antibodies to Quantum Dots for Labeling Cell Surface Receptors in Mammalian Cells. Gopal Iyer, Jianmin Xu, and Shimon Weiss. Bioconjugation Protocols. 2011, 751 pp 553-563. January 2, 2011. DOI: 10.1007/978-1-61779-151-2-34.

Applicable patents and legal notices are available at legal notices.

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