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Thiol-dPEG®₈-acid (QBD-10183)



Thiol-dPEG®8-acid, product number QBD-10183, is a hydrophilic, flexible compound containing a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain. A sulfhydryl group and a propionic acid group form the linker’s two termini. The sulfhydryl moiety reacts with other thiols, maleimido groups, the SPDP reactive group, and bromoacetamido groups, and forms dative bonds with gold and silver. Reactions of Thiol-dPEG®8-acid with sulfhydryls or SPDP form disulfide bonds. With maleimido and bromoacetamido compounds, Thiol-dPEG®8-acid reacts to form thioether linkages. Gold and silver form dative bonds with the sulfhydryl group on Thiol-dPEG®8-acid. The propionic acid moiety couples with free amines to form amide bonds.

This product can be used to modify gold and silver surfaces, crosslink amines and thiols, and thiolate biomolecules. The dPEG®8 linker imparts water solubility to the conjugate. In published scientific literature, Thiol-dPEG®8-acid has
Labeled polyester nanoparticles with 18F;
Functionalized gold nanoparticles with RGD peptides;
Demonstrated proof-of-concept detection of pathogenic biomarkers at nM limits; and,
Functionalized a localized surface plasmon resonance (LSPR) biosensor integrated with a microfluidic chip.


Unit Size100 mg, 1000 mg
Molecular Weight458.57; single compound
Chemical formulaC₁₉H₃₈O₁₀S
Purity> 98%
SpacersdPEG® Spacer is 28 atoms and 32.5 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. CdSe nano-particles coated with thiol-terminated oligo(ethylene oxide) for protein targeting reagent. Yukari Ito and Hiromori Tsutsumi. NSTI-Nanotech. 2009, 2. 2009.
  3. Novel 18F labeling strategy for polyester-based
    NPs for in vivo PET-CT imaging. Primiano Pio Di Mauro, Vanessa Gómez-Vallejo, Zurine Baz, Jordi Llop, and Salvador Borros. Bioconjugate Chemistry. 2015. February 24, 2015. DOI: 10.1021/acs.bioconjchem.5b00040.
  4. Cyclic RGD Functionalized Gold Nanoparticles for Tumor Targeting. Daniela Arosio, Leonardo Manzoni, Elena M. V. Araldi, and Carlo Scolastico. Bioconjugate Chem. 2011, 22 (4), pp 664–672. March 24, 2011. DOI: 10.1021/bc100448r.
  5. Biomarker-Mediated Disruption of Coffee-Ring Formation as a Low Resource Diagnostic Indicator. Joshua R. Trantum, David W. Wright, and Frederick R. Haselton. Langmuir, 2012, 28 (4), pp 2187–2193. December 9, 2011.
  6. Enantioselective analysis of melagatran via a LSPR biosensor integrated with microfluidic chip. Longhua Guo, Yuechun Yin, Rong Huang, Bin Qiu, Zhenyu Lin, HH Yang, Jianrong Li and Guo Nan Chen. Lab on a Chip. 2012, 20 (12), pp 3901-3906. June 15, 2012. DOI: 10.1039/C2LC40388A.
  7. Magnetic Nanoparticle Tracking for One-Step Protein Seperation and Binding Kinetics Analysis. Yunlei Zhao, Guangzhong Ma, Shaopeng Wang. Journal of The Electrochemical Society. 2022. May 11, 2022.
  8. Charge-Sensitive Optical Detection of Binding Kinetics between Phage-Displayed Peptide Ligands and Protein Targets. Runli Liang, Yingnan Zhang, Guangzhong Ma, Shaopeng Wang. MDPI. 2022. Biosensors 2022, 12(6), 394. June 8, 2022.

Applicable patents and legal notices are available at legal notices.

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