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t-boc-N-EDA (QBD-10226)



t-boc-N-EDA, product number QBD-10226, CAS number 57260-73-8, is the boc-protected form of ethylenediamine. It is not a dPEG® product. However, it can be useful in bioconjugation reactions where an exceptionally short, monoprotected, homobifunctional crosslinker is needed. The free primary amine reacts with activated esters of carboxylic acids (for example, the N-hydroxysuccinimidyl ester, also known as NHS) to form amide bonds. Treatment of the resulting conjugate with acid (for example, TFA) removes the boc protecting group from the protected amine, leaving a primary amine that is free to react.


Unit Size1000 mg
Molecular Weight160.21; single compound
Chemical formulaC₁₅H₃₂N₂O₅
Purity> 98%
SpacersdPEG® Spacer is 4 atoms and 3.8 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.
  2. DEVD-NucView 488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells. Hui Cen, Fei Mao, Ida Aronchik, Rholinelle Joy Fuentes, and Gary L. Firestone. The FASEB Journal. 2008, (22), pp 2243-2252. July 2010. DOI: 10.1096/fj.07-099234.

Applicable patents and legal notices are available at legal notices.

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