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t-boc-N-amido-dPEG®₄-acid (QBD-10220)

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Description

t-boc-N-amido-dPEG®4-acid, product number QBD-10220, is a boc-protected amino-PEG-acid designed for use in Boc-based peptide chemical synthesis. This product allows the insertion of a short hydrophilic PEG linker into a growing PEG chain or on an amino acid side chain in the peptide. The Boc protecting group removes relatively easily under acidic conditions.

t-boc-N-amido-dPEG®4-acid can be used in Boc solid-phase peptide synthesis to insert a discrete PEG linker/spacer at the N-terminus of a peptide chain or to add a short (16 atoms) dPEG® onto the side chain of an amino acid such as lysine or ornithine. The Boc protecting group can be cleaved using TFA, HF, or trifluoromethane sulfonic acid (TFMSA). Insertion of t-boc-N-amido-dPEG®4-acid at the N-terminus of a peptide allows the creation of a flexible, hydrophilic bridge to the C-terminus of another peptide.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight365.42; single compound
Chemical formulaC₁₆H₃₁NO₈
CAS756525-91-4
Purity> 98%
SpacersdPEG® Spacer is 17 atoms and 19.2 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC or DMSO.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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