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MAL-dPEG®₃-Lipoamide (QBD-10817)

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Description

MAL-dPEG®3-Lipoamide, product number 10817, is a heterobifunctional crosslinker functionalized with a maleimidopropyl group and a lipoic acid moiety on opposite ends of a short (27 atoms, 31.1 Å), single molecular weight, discrete PEG (dPEG®) crosslinker. The lipoic acid moiety forms dative bonds with gold, silver, and other metals and can be used to coat or passivate metal surfaces. The maleimide group forms stable thioether bonds with free thiols and can be used to immobilize a sulfhydryl-containing biomolecule such as a peptide or antibody fragment to a metal surface through the dPEG®-lipoamide linkage. The flexible, non-immunogenic, hydrophilic dPEG® linker adds water solubility and increases the conjugate’s hydrodynamic volume.

Specifications

Unit Size100mg, 1000mg
Molecular Weight559.74; single compound
Chemical formulaC₂₅H₄₁N₃O₇S₂
CAS1334172-72-3
Purity> 98%
SpacersdPEG® Spacer is 27 atoms and 31.1 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, DMA or DMSO. Limited solubility in acetonitrile.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), pp. 188-190, 458-497, 924-935.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Focal adhesion regulation through microcontact printing of protein nanoparticles on self-assembled monolayers for cell guidance. Albert Martinez Moreno. DUGiDocs. 2016, June 1, 2016. DOI: http://hdl.handle.net/10256/12960.

Applicable patents and legal notices are available at legal notices.

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