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m-dPEG®₄-Azide (Azido-m-dPEG®₄) (QBD-10532)

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Description

m-dPEG®4-azide, product number QBD-10532, also known as azido-m-dPEG®4, is a monodispersed PEG product used in click chemistry applications. A non-reactive, charge-neutral methyl group and an alkyne-reactive azido group, respectively, terminate the two ends of the short (14 atoms), single molecular weight, discrete PEG (dPEG®) spacer. Both metal-catalyzed (Cu(I), Ru) azide-alkyne cycloaddition (CuAAC, RuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC) work with this product. Possible click chemistry-based applications for this product include the construction of dendrimers and hydrogels and the modification of alkyne-functionalized surfaces or biomolecules containing alkyne groups.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight233.26; single compound
Chemical formulaC₉H₁₉N₃O₄
CAS606130-90-9
Purity> 98%
SpacersdPEG® Spacer is 14 atoms and 15.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Clickable Poly(ethylene glycol)-Microsphere-Based Cell Scaffolds. Peter K. Nguyen, Christopher G Snyder, Jason D. Shields, Amanda W. Smith, Donald L. Elbert. Macromolecular Journals. 2013, 214 (8) 948-956. March 4, 2013. DOI: 10.1002/macp.201300023.

Applicable patents and legal notices are available at legal notices.

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