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m-dPEG®₄-amine (QBD-10175)

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Description

m-dPEG®4-amine, product number QBD-10175, is a short, water-soluble, single molecular weight, discrete polyethylene glycol (dPEG®) chemical modification reagent. A methyl group terminates one end of the molecule. The reactive terminus opposite the methyl group is a primary amine. This product reacts with carboxylic acids and their active esters to form amide bonds.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight207.27; single compound
Chemical formulaC₉H₂₁NO₄
CAS85030-56-4
Purity> 98%
SpacersdPEG® Spacer is 14 atoms and 15.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.
  2. De Novo Synthesis and Cellular Uptake of Organic Nanocapsules with Tunable Surface Chemistry. Kun Huang, Amy Jacobs, and Javid Rzayev. Biomacromolecules. 2011, 12 (6), pp 2327–2334. May 12, 2011. DOI: 10.1021/bm200394t.
  3. Nanoscale Patterning of Surfaces via DNA Directed Spider Silk Assembly. Anton Molina, Thomas Scheibel, and Martin Humenik. Biomacromolecules. 2018. November 20, 2018. DOI: 10.1021/acs.biomac.8b01333.
  4. FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition. Chenjie Xu, Zhenglong Yuan, Nathan Kohler, Jaemin Kim, Maureen A. Chung and Shouheng Sun. J. Am. Chem. Soc. 2009, 131 (42) pp 15346–15351. October 1, 2009. DOI: 10.1021/ja905938a.
  5. Size-Exclusion Properties of Nanoporous Films Derived from Polystyrene−Poly(methylmethacrylate) Diblock Copolymers Assessed Using Direct Electrochemistry of Ferritin. Yongxin Li and Takashi Ito. Anal. Chem. 2009, 81 (2) pp 851–855. December 10, 2008. DOI: 10.1021/ac802201w.
  6. Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging. Ignacio Melgar-Asensio, Irawati Kandela, Fraser Aird, Soesiawati R. Darjatmoko, Cristobal de los Rios, Christine M. Sorenson, Daniel M. Albert, Nader Sheibani, and Jack Henkin. Investigative Opthalmology & Visual Science. 2018, 59 (10) pp 4071-4081. July 6, 2018. DOI: 10.1167/iovs.18-24087.
  7. Benzene tricarboxamide derivatives with lipid and ethylene glycol chains self-assemble into distinct nanostructures driven by molecular packing, Nada Aljuaid a, Mark Tully b, Jani Seitsonen c, Janne Ruokolainen c and Ian W. Hamley, ChemComm, 2021, 57, 8360, 07/27/2021, DOI: 10.1039/d1cc03437e

Applicable patents and legal notices are available at legal notices.

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