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m-dPEG®₃₆-amine (QBD-10908)

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Description

m-dPEG®36-amine, product number QBD-10908, is a non-immunogenic, water-soluble chemical modification reagent. The product contains a single molecular weight, discrete-length polyethylene glycol (dPEG®) chain terminated on one end with a methyl group and on the other end with a reactive primary amine. The linker length is 109 atoms (130.0 Å). The amino group reacts with carboxylic acids (and their active esters), aldehydes, and ketones. Reacting the amino group with aldehydes or ketones forms a labile imine (Schiff base) that can be reduced to a secondary amine under mild conditions to provide greater stability to the conjugate. Reacting carboxylic acids or their active esters with m-dPEG®36-amine forms stable amide bonds. Uses for this product include passivating surfaces and coating biomolecules.

Biomolecules modified with m-dPEG®36-amine display enhanced water solubility, increased hydrodynamic volume, and reduced immunogenicity. This product reacts quickly with active esters of carboxylic acids (for example, NHS esters and TFP esters) to form amide bonds. Also, it forms amide bonds directly with carboxylic acids using the carbodiimide EDC.

m-dPEG®36-amine is potentially useful in numerous applications. Such applications include the following:
Passivating nanoparticle surfaces, including the surfaces of carbon nanotubes and graphene oxide;
Creating a non-immunogenic “”stealth”” coating for liposomes and micelles;
Increasing the hydrodynamic volume of small molecules, including peptides and antibody fragments; and,
Increasing the water solubility of hydrophobic molecules.

Specifications

Unit Size100mg, 1000mg
Molecular Weight1616.95; single compound
Chemical formulaC₇₃H₁₄₉NO₃₆
CAS32130-27-1
Purity> 97%
SpacersdPEG® Spacer is 109 atoms and 130.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetonitrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; IBSN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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