m-dPEG®₁₂-Lipoamide (QBD-10801)

Description

m-dPEG®12-Lipoamide, product number QBD-10801, is a medium-length (46 atoms), amphiphilic, methyl-terminated, monodisperse PEG product functionalized with lipoic acid and designed to modify metal surfaces such as gold or silver. The primary application of this product is the stable passivation of metal surfaces through the use of lipoic acid, which forms two dative bonds with gold or silver, conjugated to a short, monodispersed PEG spacer. Because the terminal dithiolane unit forms two dative bonds with metals, it is consequently more stable on the metal surface than comparable compounds containing a single sulfhydryl group that can create a dative bond. The amphiphilic, non-antigenic, monodispersed PEG spacer imparts water solubility to and increases the hydrodynamic volume of conjugated molecules and surfaces.

m-dPEG®12-lipoamide was designed for stable passivation of gold or silver surfaces. For useful surface coating, it may prove helpful to create a mixed layer consisting of m-dPEG®12-lipoamide and another, longer dPEG® product with a lipoamido group on one end and reactive, affinity, or other functional groups on the opposite end. Thus, the shorter m-dPEG®12-lipoamide will form a uniform coating of methyl-terminated PEG above the metal surface, and the longer dPEG® product will rise above the dPEG® coating intermittently throughout the surface layer.

Specifications

Documents

References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0), pp. 188-190, 458-497, 924-935.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Self-Assembled Quantum Dot-Sensitized Multivalent DNA Photonic Wires. Kelly Boeneman, Duane E. Prasuhn, Juan B. Blanco-Canosa, Philip E. Dawson, Joseph S. Melinger, Mario Ancona, Michael H. Stewart, Kimihiro Susumu, Alan Huston, and Igor L. Medintz. J. Am. Chem. Soc., 2010, 132 (51), pp 18177–18190 December 8, 2010. DOI: 10.1021/ja106465x.

PEGylated Luminescent Gold Nanoclusters: Synthesis, Characterization, Bioconjugation, and Application to Oneand Two-Photon Cellular Imaging. Eunkeu Oh, Fredrik Fatemi, Marc Currie, James B. Delehanty, Thomas Pons, Alexandra Fragola, Sandrine L´evˆeque-Fort, Ramasis Goswami, Kimihiro Susumu, Alan L. Huston, and Igor L. Medintz. Particle & Particle Systems Characterization 2013, (30), pp 1-13. February 5, 2013. DOI: 10.1002/ppsc.201200140.

Gastrointestinal Bioavailability of 2.0 nm Diameter Gold Nanoparticles. Candice A. Smith, Carrie A. Simpson, Ganghyeok Kim, Carly J. Carter, and Daniel L. Feldheim. ACS Nano. 2013, 7 (5) pp 3991–3996. April 21, 2013. DOI: 10.1021/nn305930e.