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Hydroxy-dPEG®₂₄-TFP ester (QBD-11349)

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Description

Hydroxy-dPEG®24-TFP ester, product number QBD-11349, is a long (76 atoms, 88.8 Å), hydroxy-terminated, single molecular weight, discrete polyethylene glycol (dPEG®) compound functionalized with a 2,3,5,6-tetrafluorophenyl (TFP) ester for conjugation to primary and secondary amines. This product can be used for modification of amine-functionalized surfaces (e.g., silica, glass), modification of proteins and peptides at accessible amine sites on the molecules, the construction of discrete PEG dendrimers, and many other applications. The free hydroxy end of the dPEG® spacer can be functionalized for further reactions or left unmodified to increase hydrophilicity or modify the charge of conjugate molecules and surfaces.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1295.40; single compound
Chemical formulaC₅₇H₁₀₂F₄O₂₇
CASN/A
Purity> 97%
SpacersdPEG® Spacer is 76 atoms and 88.8 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)DCM, Methanol, Ethanol, Acetonitrile, Water, Ethyle Acetate, or Acetone.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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