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dPEG®₁₂-diol (QBD-10261)



dPEG®12-diol, product number QBD-10261, is a homobifunctional, monodispersed (single molecular weight and chain length) PEG diol that is useful for creating new PEG products. Both ends terminate with hydroxy groups. The primary use of this product is as a building block for other products. An unlimited number of functional or protecting groups can modify the termini of dPEG®12-diol. Moreover, dPEG®12-diol can function as a crosslinker by reacting the terminal alcohols with active carboxylic acid esters or isothiocyanates. Conjugates containing PEG have increased hydrodynamic volume and hydrophilicity.


Unit Size100 mg, 1000 mg
Molecular Weight546.65; single compound
Chemical formulaC₂₄H₅₀O₁₃
Purity> 98%
SpacersdPEG® Spacer is 37 atoms and 42.8 Å
Typical solubility properties (for additional information contact Customer Support)Methylene chloride, Acetontrile, DMAC, DMSO or water.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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