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DOTA-tris(TBE)-amido dPEG®₁₁-MAL (QBD-11166)



DOTA-tris(TBE)-amido-dPEG®11-MAL, product number QBD-11166, is a thiol-reactive DOTA compound containing a medium-length (37 atoms, 44.5 Å), single molecular weight, discrete polyethylene glycol (dPEG®) spacer between the DOTA and the maleimide groups. The macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) moiety is protected with tert-butyl ester (TBE) groups on the four acetate units.

DOTA is a popular, effective bifunctional chelator that is used in radiopharmaceutical applications (radioimaging, radiotherapeutics) that require trivalent isotopes of yttrium or lanthanides. This form of DOTA has the four acetate groups protected with tert-butyl esters (TBE). This intermediate DOTA form is not an effective chelator, but it is useful in situations where the DOTA needs to be incorporated into the molecule at an early stage of development. 


Unit Size50 mg, 100 mg, 500 mg
Molecular Weight1250.52; single compound
Chemical formulaC₅₉H₁₀₇N₇O₂₁
Purity> 95%
SpacersdPEG® Spacer is 37 atoms and 44.5 Å
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, DMSO, DMAC, DMF, or Acetonitrile.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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