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DOTA-tris(acid)-amido-dPEG®₂₄-amido-dPEG®₂₄-DSPE (QBD-11384)

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Description

DOTA-tris(acid)-amido-dPEG®24-amido-dPEG®24-DSPE, product number QBD-11384, is designed incorporation of lanthanide radionuclides into liposomes or micelles for transport and delivery in radiopharmaceutical applications such as radioimaging and radiotherapeutics. The molecule consists of the macrocycle 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) coupled to a long (152 atoms, 180.0 Å) single molecular weight, discrete polyethylene glycol (dPEG®) spacer and terminated with 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine (DSPE). The dPEG® spacer consists of two dPEG®24 linkers joined by an amide bond with the functional groups at either end. Effectively, this is a dPEG®48 spacer with a molecular weight slightly more than 2000 Daltons (PEG2000).

DOTA, a highly popular bifunctional chelator, forms thermodynamically stable, kinetically inert complexes with Ln(III) ions, such as yttrium. Thus, DOTA has become the preferred ligand for targeted radiopharmaceutical applications that use lanthanide isotopes. QBD-11384 can be used in liposomes or micelles to deliver metal radioisotopes to targets of interest in vitro or in vivo for imaging or therapeutic applications. The dPEG® surface coating will reduce or eliminate opsonization. Consequently, more liposomes or micelles will reach the target, leading to higher effectiveness and lower dosing requirements.

Specifications

Unit Size25 mg, 100 mg
Molecular Weight3391.14; single compound
Chemical formulaC₁₅₉H₃₁₀N₇O₆₅P
CASN/A
Purity> 95%
SpacersdPEG® Spacer is 152 atoms and 180.0 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, Acetonitrile, DMSO, or Chloroform
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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