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DBCO-dPEG®₃₆-TFP ester (QBD-10598)



DBCO-dPEG®36-TFP ester, product number QBD-10598, is a heterobifunctional, bioorthogonal crosslinker designed to join azides and amines across a long (122 atoms, 137.5 Å), flexible, hydrophilic, single molecular weight, discrete PEG (dPEG®) spacer. The tetrafluorophenyl (TFP) ester reacts specifically with free amines to form amide bonds; the optimum reaction pH is 7.5 – 8.0. The dibenzylcyclooctyne (DBCO) moiety selectively forms triazole linkages with azides via a click chemistry reaction known as strain-promoted azide-alkyne cycloaddition (SPAAC), also known as copper-free click chemistry. The amphiphilic dPEG® linker increases conjugates’ hydrodynamic volumes and water solubility, and it can be used to create space in sterically crowded supramolecular constructs.


Unit Size25mg, 100mg , 500mg
Molecular Weight2124.38
Chemical formulaC₁₀₁H₁₆₆F₄N₂O₄₀
Purity> 97%
SpacersdPEG® Spacer is 122 atoms and 137.5 Å
Typical solubility properties (for additional information contact Customer Support)Methanol, Dichloromethane, Acetonitrile, or N,N-dimethylacetamide
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.


Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

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