Vector Laboratories is closed for the President’s Day on Monday, February 19th. We will be back in the office on Tuesday, February 20th.
We will respond to emails upon our return. Have a wonderful day.

Bromoacetamido-dPEG®₂₃-azide (QBD-11205)

[text-backorder]

Description

Bromoacetamido-dPEG®23-azide, product number QBD-11205, is discrete PEG (dPEG®) crosslinker that facilitates the crosslinking of free thiols with click chemistry alkyne partners across a long (76 atoms, 88.5 Å) single molecular weight PEG bridge.

The long, amphiphilic dPEG® linker adds hydrodynamic volume to conjugate molecules and increases their water solubility. The flexible, non-immunogenic spacer reduces or eliminates renal clearance and helps shield conjugates from opsonization through the increased hydrodynamic volume the dPEG® linker imparts.

The bromoacetate moiety reacts chemoselectively with free thiols at pH >8.0. It is an alternative to the maleimide group and is used in situations where the target molecule needs to be at a high pH. The azide group reacts with a suitable alkyne partner via metal-catalyzed (Cu, Ru) or strain-promoted (copper-free) click chemistry. Moreover, Bromoacetamido-dPEG®23-azide is stable, unlike MAL-PEG-azide constructs, which are somewhat unstable.

Specifications

Unit Size100 mg, 1000 mg
Molecular Weight1220.24; single compound
Chemical formulaC₅₀H₉₉BrN₄O₂₄
CASN/A
Purity> 98%
SpacersdPEG® Spacer is 76 atoms and 88.5 Å
ShippingAmbient
Typical solubility properties (for additional information contact Customer Support)Methylene Chloride, Methanol, Acetone, Chloroform, DMSO, DMAC, or DMF.
Storage and handling-20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.



References

Greg T. Hermanson, Bioconjugate Techniques, 2nd Edition, Elsevier Inc., Burlington, MA 01803, April, 2008 (ISBN-13: 978-0-12-370501-3; ISBN-10: 0-12-370501-0). Specifically see pp. 726-729 in his Chapter 18 on discrete PEG compounds for pegylation applications.

Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See chapter 18, Discrete PEG Reagents, pp.787-821, for a full overview of the dPEG® products.

Applicable patents and legal notices are available at legal notices.

How do I Request a Quote?

To request a quote for products:

  1.  Log in to VectorLabs.com
  2.  Add the items you wish to quote to the cart;
  3.  View your cart;
  4.  Click on the “Request a Quote” button found below the items in your cart;
  5.  Download your quote