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Bis-dPEG®₄-TFP ester (QBD-10085)

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Description

Bis-dPEG®4-TFP ester, product number QBD-10085, is a homobifunctional, amine-reactive crosslinker. A pair of hydrolytically stable tetrafluorophenyl (TFP) esters terminate each end of a discrete PEG (dPEG®) linker. The TFP esters react rapidly with primary and secondary amines and do not cross-react with other groups. One application for this product is the crosslinking of closely associated biomolecules in a cellular matrix or lysate. However, the possible applications of Bis-dPEG®4-TFP ester are as varied and numerous as the user can envision.

Specifications

Unit Size 100 mg, 1000 mg
Molecular Weight 590.41; single compound
Chemical formula C₂₄H₂₂F₈O₈
CAS N/A
Purity > 98%
Spacers dPEG® Spacer is 16 atoms and 18.1 Å
Shipping Ambient
Typical solubility properties (for additional information contact Customer Support) Methylene chloride, DMAC or DMSO
Storage and handling -20°C; Always let come to room temperature before opening; be careful to limit exposure to moisture and restore under an inert atmosphere; stock solutions can be prepared with dry solvent and kept for several days (freeze when not in use). dPEG® pegylation compounds are generally hygroscopic and should be treated as such. This will be less noticeable with liquids, but the solids will become tacky and difficult to manipulate, if care is not taken to minimize air exposure.

References

  1. Greg T. Hermanson, Bioconjugate Techniques, 3rd Edition, Elsevier, Waltham, MA 02451, 2013, ISBN 978-0-12-382239-0; See Chapter 18, Discrete PEG Reagents, pp. 787-821, for a full overview of the dPEG® products.

  2. Holistic Assessment of Covalently Labeled Core–Shell Polymeric Nanoparticles with Fluorescent Contrast Agents for Theranostic Applications. Tiffany P. Gustafson, Young H. Lim, Jeniree A. Flores, Gyu Seong Heo, Fuwu Zhang, Shiyi Zhang, Sandani Samarajeewa, Jeffery E. Raymond, and Karen L. Wooley. Langmuir. 2014, January 6, 2014. DOI: 10.1021/la403943w.

Applicable patents and legal notices are available at legal notices.

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